A tornado has caused “multiple injuries and multiple deaths” in Missouri, US officials have said.
The tornado moved through Bollinger County, about 50 miles south of St Louis, on Wednesday morning, said Sergeant Clark Parrott of the Missouri State Highway Patrol.
Officials said a search and rescue operation had been launched and it was currently not known how many people had been injured or killed.
There are reports 85 million Americans are at risk from the extreme weather on Wednesday.
It comes after the storm system had also hit parts of Illinois, Iowa and Michigan.
